Regenerative Medicine 2023
Utilizing our body's natural powers
Regenerative Medicine
Definition: medicine focused on new treatments to heal tissues and organs, and restore function lost due to aging, disease, damage or defects.
The modalities of regenerative medicine take inspiration from endogenous compounds (chemicals originating within the body). The human body has a natural ability to heal itself in numerous ways.
“Nature is always more subtle, more intricate, more elegant than what we are able to imagine.” - Carl Sagan
I think this idea of viewing nature as the ultimate technology aligns with a lot of my beliefs in a variety of industries. I will be expanding upon this concept in upcoming posts about computing, manufacturing, agriculture, freshwater access, and more!
Emerging frontiers in regenerative medicine (Nature.org - May 25, 2023)
Recent Discoveries
“Third patient cured of HIV after receiving stem cell cancer treatment” (Feb 20, 2023)
“New injectable cell therapy could resolve osteoarthritis” (Apr 22, 2023)
“Cartilage activated immune cells that target inflammation, combined with progenitor cells aid tissue regeneration…"
“…found to have the ability to reverse cartilage damage in the synovial membrane and diminish the inflammation as well.”
“UVA Discovers Repair Process That Fixes Damaged Hearing Cells” (July 6, 2023)
“…a protein called XIRP2, which has the ability to sense damage to the cores, which are made of a substance called actin. Shin and his team found that XIRP2 first senses damage, then migrates to the damage site and repairs the cores by filling in new actin.”
Stem Cell Therapies
^ in depth interview about stem cells and regenerative med
Progenitor Cells
→ differentiates into specialized cells
→ unable to renew itself
Adipose Derived Stem Cells
Young vs Old stem cells
Umbilical Cord Stem Cells
Exosome Therapy
What are exosomes? An extra-cellular vesicle that contains a multitude of compounds.
It appears that exosomes are a part of how stem cells work during differentiation.
The advantage this may have over stem cells is that it is not living matter. This eliminates the runaway risk of cancer where faulty DNA can cause tumors.
Gene Therapies
Gene Therapies (Harvard Stem Cell Institute)
Cellular reprogramming is no longer a thing of science fiction. Soon we will have genetically modified humans ubiquitously walking amongst us.
Follistatin Gene Therapy
Longevity Gene Therapy
“Anti-ageing gene injections could rewind your heart age by 10 years” (Jan 23, 2023)
Cancer
Genetic Conditions
Designer Babies?
Gene Editing Vectors
Adeno-Associated Virus (AAV)
High Capacity Cytomegalovirus Vector
“New intranasal and injectable gene therapy for healthy life extension”
Mini Circles
“Minicircle Biopharmaceuticals–An Overview of Purification Strategies” (Jan 13, 2021)
“Minicircle DNA vectors for gene therapy: advances and applications“ (Dec 24, 2014)
^ backed by Peter Thiel
3D Bioprinting/Organ Regeneration
“This company is about to grow new organs in a person for the first time” (Aug 23, 2022)
A volunteer with severe liver disease will soon undergo a procedure that could lead them to grow a second liver.
Hormone Replacement Therapy
HRT for Women
Peptides
BPC-157
TB-500
GHK-Cu
An emerging exciting peptide that has a variety of amazing effects
“The potential of GHK as an anti-aging peptide” (Jan 25, 2022)
Semax/Selank (Melanocortin receptors)
These peptides are commonly used as a nasal spray for brain health effects. It is even prescribed in Russia for post-concussion, stroke, and other brain damage
“Semax Research (CanPeptides)”
Semax Affects Resting Brain Structure
Semax in the Setting of Stroke
Semax and Gene Expression in the Brain
Semax and Cognitive Performance
Semax and Depression
Repaired brain chemistry changes after early SSRI exposure
“Semax and selank inhibit the enkephalin-degrading enzymes from human serum“ (May 2001)
Increases enkephalin (endogenous opioid) levels
“Melanocortin Regulation of Inflammation” (Oct 9, 2019)
Semaglutide (GLP-1 receptors)
Further Readings
There are even more therapies and longevity tech available nowadays. I will continue to observe evidence about which modalities are proving themselves to be effective. You can expect a lot more about this topic in the future!
